Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose
| Autor: | Svetlana Trajkovic, Aleksandra Petrovic, Radmila Popovic, Nebojsa Cvetkovic, Dragica Popadic, Zorica Djuric, Svetlana Ibrić |
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| Rok vydání: | 2009 |
| Předmět: |
Drug Liberation
Materials science Chemistry Pharmaceutical Pharmacology toxicology 02 engineering and technology Sustained release dosage forms Methylcellulose HPMC/carbomer matrices 030226 pharmacology & pharmacy Excipients 03 medical and health sciences Matrix (mathematics) 0302 clinical medicine Hypromellose Derivatives Theophylline Drug Discovery Solubility Chromatography Mixture experimental design Organic Chemistry In vitro tests 021001 nanoscience & nanotechnology Kinetics Acrylates Delayed-Action Preparations Drug Design Drug release Molecular Medicine Spectrophotometry Ultraviolet 0210 nano-technology Sustained release dosage form Dissolution Tablets |
| Zdroj: | Archives of Pharmacal Research |
| ISSN: | 1976-3786 |
| Popis: | Using mixture experimental design, the effect of carbomer (Carbopol((R)) 971P NF) and hydroxypropylmethylcellulose (Methocel((R)) K100M or Methocel((R)) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile. |
| Databáze: | OpenAIRE |
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