Metal-free electrochemical fluorodecarboxylation of aryloxyacetic acids to fluoromethyl aryl ethers

Autor:	John D. Herszman, Yuji Kurimoto, Sven Ruf, Siegfried R. Waldvogel, Goswinus H. M. de Kruijff, Aaron Schüll, Michael Berger
Rok vydání:	2020
Předmět:	Chemistry chemistry.chemical_compound chemistry Metal free Supporting electrolyte Decarboxylation Aryl General Chemistry Electrochemistry Electrosynthesis Combinatorial chemistry Fluoride
Zdroj:	Chemical Science
ISSN:	2041-6539 2041-6520
DOI:	10.1039/d0sc02417a
Popis:	Electrochemical decarboxylation of aryloxyacetic acids followed by fluorination provides easy access to fluoromethyl aryl ethers. This electrochemical fluorodecarboxylation offers a sustainable approach with electric current as traceless oxidant. Using Et3N·5HF as fluoride source and as supporting electrolyte, this simple electrosynthesis affords various fluoromethoxyarenes in yields up to 85%. Electrochemical decarboxylation of aryloxyacetic acids followed by fluorination provides easy access to fluoromethyl aryl ethers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb31b7368895c4c2cc9eab34a830d0f https://doi.org/10.1039/d0sc02417a Zobrazit plný text záznamu