Amelioration of testicular damages in renal ischemia/reperfusion by berberine: An experimental study
| Autor: | Shabnam Malekpour Mansourkhani, Seyed Mohammad Owji, Firouzeh Gholampour |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lh
medicine.medical_specialty QH471-489 lcsh:QH471-489 Ischemia testis lcsh:Gynecology and obstetrics FSH chemistry.chemical_compound Follicle-stimulating hormone Berberine Internal medicine berberine medicine lcsh:Reproduction lcsh:RG1-991 Creatinine Renal ischemia business.industry Reproduction Acute kidney injury Obstetrics and Gynecology Gynecology and obstetrics Left Testis medicine.disease ischemia/reperfusion Endocrinology Reproductive Medicine chemistry acute kidney injury RG1-991 fsh business Luteinizing hormone Research Article |
| Zdroj: | International Journal of Reproductive BioMedicine, Vol 17, Iss 11, Pp 799-806 (2019) International Journal of Reproductive Biomedicine International Journal of Reproductive BioMedicine, Vol 17, Pp 799-806 (2019) |
| ISSN: | 2476-3772 2476-4108 |
| Popis: | Background Ischemic acute kidney injury is associated with an inflammatory reaction. Objective In the current study, berberine was assessed for its effect on the functional disorders and histological damages of testis induced by renal ischemia/reperfusion (I/R). Materials and Methods Twenty-eight adult male Wistar rats (260-300 gr) were equally divided into four groups (n = 7/each): sham and I/R groups which received distilled water as well as berberine (BBR) and BBR + I/R groups which received berberine (15 mg/kg/day) orally seven days before the surgery. In both groups of sham and BBR, renal arteries were not clamped. Renal I/R was induced by occluding right and left renal artery for 45 min followed by a 24 hr reperfusion period. Blood samples were taken for determining the plasma levels of creatinine, urea nitrogen, FSH (follicle stimulating hormone), LH (luteinizing hormone), and testosterone. Then the rats were killed under deep anesthesia and the left testis was immediately isolated and preserved. Results The renal I/R injury led to testicular histological damages accompanied with increased plasma levels of creatinine, urea nitrogen, LH, and FSH, as well decrease of plasma testosterone concentration at the end of 24 hr reperfusion (All p < 0.001, except for FSH p < 0.01). Berberine diminished histological damage to the testis and attenuated the increase in plasma creatinine, urea nitrogen, LH, FSH, and decrease in plasma testosterone concentration in the BBR + I/R group (All p < 0.001). Conclusion These results suggest that ischemic acute renal failure induces functional disorders and tissue damages in testis of rat, which was improved through the administration of berberine. |
| Databáze: | OpenAIRE |
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