Chemoembolization Plus Microwave Ablation vs Chemoembolization Alone in Unresectable Hepatocellular Carcinoma Beyond the Milan Criteria: A Propensity Scoring Matching Study
Autor: | Tian-Zhi An, Jie Tan, Tian Tang, Jun-Xiang Li, Hui-Zhou Li, Yu-Dong Xiao |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Percutaneous business.industry Proportional hazards model medicine.medical_treatment Microwave ablation transarterial chemoembolization Liver transplantation Milan criteria medicine.disease survival Gastroenterology Log-rank test microwave ablation Internal medicine Hepatocellular carcinoma Propensity score matching Medicine propensity score-matching business Journal of Hepatocellular Carcinoma Original Research |
Zdroj: | Journal of Hepatocellular Carcinoma |
ISSN: | 2253-5969 |
Popis: | Hui-Zhou Li,1 Jie Tan,1 Tian Tang,2 Tian-Zhi An,3 Jun-Xiang Li,4 Yu-Dong Xiao1 1Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Peopleâs Republic of China; 2Department of Interventional Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Peopleâs Republic of China; 3Department of Interventional Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550002, Peopleâs Republic of China; 4Department of Interventional Radiology, Guizhou Medical University Affiliated Cancer Hospital, Guiyang, 550004, Peopleâs Republic of ChinaCorrespondence: Yu-Dong XiaoDepartment of Radiology, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Peopleâs Republic of ChinaTel +86 13637403027Fax +86 731-85292116Email xiaoyudong222@csu.edu.cnPurpose: Transarterial chemoembolization (TACE) is recommended in patients with unresectable HCC beyond the Milan criteria (MC). However, the long-term efficacy of TACE remains unsatisfactory. Percutaneous microwave ablation (MWA) is a curative therapy for early-stage HCC that provides better local tumor control than TACE; however, MWA is limited for large or multifocal lesions. We aimed to compare treatment efficacy and downstaging rate following combined TACE-MWA and TACE alone in patients with unresectable HCC beyond the MC.Patients and Methods: Patients with unresectable HCC beyond the MC who underwent either TACE-MWA (n=91) or TACE alone (n=140) at four medical institutions were included. Potential influencing factors on overall survival (OS) and progression-free survival (PFS) were included in the Cox regression analysis. Propensity-score matching of patients treated with TACE-MWA and TACE alone was performed. Differences in OS and PFS were compared with the Log rank test. Patients who met the University of California, San Francisco criteria were eligible for assessment of the probability of downstaging within the MC. Downstaging rate was compared between the two groups.Results: In multivariate analysis, treatment with TACE alone was an independent predictor of poor PFS (P=0.011) and OS (P< 0.001). Both PFS (P=0.043) and OS (P=0.002) were significantly higher in patients treated with TACE-MWA than those treated with TACE alone. The downstaging rate was higher in patients treated with TACE-MWA than those treated with TACE alone (P=0.039).Conclusion: Compared with TACE alone, TACE-MWA may offer a survival benefit in terms of OS and PFS in HCC patients beyond the MC. Additionally, TACE-MWA may provide higher probability of downstaging within the MC than TACE alone, thereby increasing the possibility of liver transplantation.Keywords: microwave ablation, transarterial chemoembolization, survival, propensity score-matching, Milan criteria |
Databáze: | OpenAIRE |
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