Cardiopharyngeal progenitor specification: multiple roads to the heart and head muscles

Autor: Fabienne Lescroart, Benjamin Swedlund
Přispěvatelé: Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels 1070, Belgium., Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), lescroart, fabienne
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Génétique du développement
Cell type
Lineage (genetic)
[SDV]Life Sciences [q-bio]
Population
Embryonic Development
Biology
General Biochemistry
Genetics and Molecular Biology
Mesoderm
03 medical and health sciences
0302 clinical medicine
Single-cell analysis
[SDV.BDD] Life Sciences [q-bio]/Development Biology
Basic Helix-Loop-Helix Transcription Factors
Animals
Humans
Cell Lineage
Progenitor cell
Muscle
Skeletal
education
[SDV.BDD]Life Sciences [q-bio]/Development Biology
030304 developmental biology
Progenitor
0303 health sciences
education.field_of_study
Heart development
Stem Cells
[SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
Gene Expression Regulation
Developmental
Neural crest
Cell Differentiation
Heart
Sciences bio-médicales et agricoles
[SDV] Life Sciences [q-bio]
[SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
PERSPECTIVES
Neural Crest
embryonic structures
Single-Cell Analysis
Biologie
Head
Neuroscience
030217 neurology & neurosurgery
Signal Transduction
Zdroj: Heart Development and Disease
Heart Development and Disease, 2019, 978-1-621823-58-2
Cold Spring Harb Perspect Biol
Cold Spring Harbor Perspectives in Biology
Popis: International audience; During embryonic development, the heartarise from various sourcesof undifferentiated mesodermal progenitors, with an additional contribution from ectodermal neural crest cells. Mesodermal cardiac progenitorsareplasticand multipotent,but are nevertheless specified to a precise heart region and cell type very early during development. Recent findings have defined both this lineage plasticity and early commitment of cardiac progenitors, using a combination of single-cell and population analyses. In this review, we discuss several aspects of cardiac progenitor specification. We discuss their markers, fate potential in vitroand in vivo, early segregation and commitment, and also intrinsic and extrinsic cues regulatinglineage restrictionfrom multipotency to a specific cell type of the heart. Finally, we also discuss the sub-divisionsof the cardiopharyngeal field, and the shared origins of the heart with other mesodermal derivatives, including head and neck muscles.
Databáze: OpenAIRE
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