Association analysis for neuronal nitric oxide synthase gene polymorphism with plasma nitrite/nitrate concentration in schizophrenia
| Autor: | Ljiljana Trajanović, Dušan Lazarević, Vladimir V. Đorđević, Vidosava B. Đorđević, Ivana Stojanovic, Tatjana Jevtovic-Stoimenov, Olivera Žikić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
ct transition NOS1 nitrite/nitrate Nitric oxide lcsh:Biochemistry chemistry.chemical_compound CT tranzicija nitriti/nitrati Nitrate single nucleotide polymorphism Internal medicine Genotype Blood plasma medicine lcsh:QD415-436 Nitrite CT transition azot-monoksid sintaza biology shizo-frenija nitric oxide synthase Nitric oxide synthase schizophrenia Endocrinology chemistry polimorfizam pojedinačnih nukleotida biology.protein Gene polymorphism |
| Zdroj: | Journal of Medical Biochemistry, Vol 33, Iss 4, Pp 364-370 (2014) Journal of Medical Biochemistry (2014) 33(4):364-370 |
| ISSN: | 1452-8266 1452-8258 |
| Popis: | Summary Background: Single nucleotide polymorphisms (SNP) of many genes, including the gene for neuronal nitric oxide syn-thase (NOS1), were found significantly associated with schizo-phrenia. According to our previously published results of increased plasma nitric oxide concentration in patients with schizophrenia, we hypothesized that the NOS1 gene polymorphism might be a cause of increased nitric oxide production in patients with schizophrenia and tested the interdependence between plasma nitrite/nitrate concentrations and SNP (a CT transition located in exon 29) of the human NOS1 gene. Methods: Nitrite/nitrate concentration was measured in blood plasma of 38 patients with schizophrenia and of 39 age and gender matched healthy persons by the colorimet-ric test. The NOS1 gene polymorphism was determined by polymerase chain reaction analysis. Results: A significantly higher plasma nitrite/nitrate concentration was found in patients with schizophrenia (97.5±33.3 μmol/L, p2=24.54, p=0.0000047). Furthermore, a significant difference in the allele frequencies between patients and controls (χ2=19.00, p Conclusions: CT transition located in exon 29 of the human NOS1 gene may be responsible for the increased plasma nitrite/nitrate levels. |
| Databáze: | OpenAIRE |
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