Aging-induced type I interferon response at the choroid plexus negatively affects brain function
| Autor: | Tony Wyss-Coray, Kuti Baruch, Zohar Barnett-Itzhaki, Ido Amit, Omer Miller, Tamara Berkutzki, Eyal David, Aleksandra Deczkowska, Dana Bezalel, Joseph M. Castellano, Michal Schwartz, Alexander Kertser |
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| Rok vydání: | 2014 |
| Předmět: |
Aging
medicine.medical_specialty Neurogenesis Hippocampus Mice Transgenic Hippocampal formation Mice Cognition Cerebrospinal fluid Internal medicine medicine Animals Cognitive decline Receptors Interferon Multidisciplinary business.industry Brain Endocrinology Gene Expression Regulation Choroid Plexus Interferon Regulatory Factors Interferon Type I Immunology Choroid plexus business Interferon type I medicine.drug Interferon regulatory factors |
| Zdroj: | Science. 346:89-93 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Excess signaling is bad for the aging brain Preventing antiviral-like responses may protect function in the aging brain. Baruch et al. monitored messenger RNA production in the choroid plexus, the interface between the blood and cerebrospinal fluid, in young and old mice (see the Perspective by Ransohoff). They detected an inflammatory response in older mice not present in the brain of young mice that was also seen in old aged human samples postmortem. Preventing signaling by the cytokine interferon-I, which normally helps in the antiviral response of the immune system, helped prevent the decrease in cognitive function seen in aged mice. Science , this issue p. 89 ; see also p. 36 |
| Databáze: | OpenAIRE |
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