Extracellular vesicles as actors in the air pollution related cardiopulmonary diseases

Autor:	Stéphanie Alkoussa, Perrine J. Martin, Sébastien Hulo, Sylvain Billet, Dominique Courcot
Přispěvatelé:	Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Université du Littoral Côte d'Opale (ULCO), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání:	2020
Předmět:	Air pollution 010501 environmental sciences Toxicology medicine.disease_cause 01 natural sciences Extracellular vesicles Extracellular Vesicles 03 medical and health sciences Air pollutants Air Pollution medicine [CHIM]Chemical Sciences Respiratory system 030304 developmental biology 0105 earth and related environmental sciences Cardiopulmonary disease Air Pollutants 0303 health sciences COPD business.industry Environmental Exposure medicine.disease 3. Good health Cardiovascular Diseases 13. Climate action Immunology Toxicity business Oxidative stress
Zdroj:	Critical Reviews in Toxicology Critical Reviews in Toxicology, Taylor & Francis, 2020, 50 (5), pp.402-423. ⟨10.1080/10408444.2020.1763252⟩
ISSN:	1547-6898 1040-8444
DOI:	10.1080/10408444.2020.1763252
Popis:	International audience; Many associations were reported between air pollution and daily mortality rates for cardiopulmonary diseases. Humans are exposed to a mixture of oxidizing gases and particles, both anthropogenic and natural. Exposure to air toxics causes or exacerbates cardiovascular damages and respiratory diseases. Numerous studies have identified the induction of oxidative stress and sustained inflammatory response as among the main known underlying pathophysiological mechanisms of air pollutants. More recently, the relationship between these mechanisms of action and the secretion of extracellular vesicles (EVs) by lung cells has been revealed. EVs have been shown to be important mediators of cellular communication in the body. The purpose of this review is to first recall the main air pollutants. Then, the cardiopulmonary diseases caused by exposure to air pollution and the pathophysiological mechanisms are presented before showing, through an exhaustive review of the literature, the involvement of EVs in the toxicity of air pollutants and the initiation of cardiopulmonary diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eaa219bb2a9c008ace4a3ccc71ff0a8 https://doi.org/10.1080/10408444.2020.1763252 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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