Magnetic nanoparticle hyperthermia for treating locally advanced unresectable and borderline resectable pancreatic cancers: the role of tumor size and eddy-current heating
Autor: | Haoming Zhou, Theodore L. DeWeese, Michele Wabler, Anilchandra Attaluri, Sri Kamal Kandala, Robert Ivkov |
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Rok vydání: | 2021 |
Předmět: |
Hyperthermia
Cancer Research medicine.medical_specialty magnetic nanoparticles lcsh:Medical technology Physiology pancreatic cancer Locally advanced Mice Nude Article 030218 nuclear medicine & medical imaging Heating 03 medical and health sciences Mice 0302 clinical medicine Borderline resectable Physiology (medical) Pancreatic cancer Medicine Animals Humans Magnetite Nanoparticles bioheat transfer Tumor size business.industry tumor size eddy currents Hyperthermia Induced medicine.disease Locally advanced pancreatic cancer Pancreatic Neoplasms lcsh:R855-855.5 030220 oncology & carcinogenesis Female Radiology business |
Zdroj: | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group International Journal of Hyperthermia, Vol 37, Iss 3, Pp 108-119 (2020) |
ISSN: | 1464-5157 |
Popis: | Purpose: Tumor volume largely determines the success of local control of borderline resectable and locally advanced pancreatic cancer with current therapy. We hypothesized that a tumor-mass normalized dose of magnetic nanoparticle hyperthermia (MNPH) with alternating magnetic fields (AMFs) reduces the effect of tumor volume for treatment. Methods: 18 female athymic nude mice bearing subcutaneous MiaPaCa02 human xenograft tumors were treated with MNPH following intratumor injections of 5.5 mg Fe/g tumor of an aqueous suspension of magnetic iron-oxide nanoparticles. Mice were randomly divided into control (n = 5) and treated groups having small (0.15 ± 0.03 cm3, n = 4) or large (0.30 ± 0.06 cm3, n = 5) tumors. We assessed the clinical feasibility of this approach and of pulsed AMF to minimize eddy current heating using a finite-element method to solve a bioheat equation for a human-scale multilayer model. Results: Compared to the control group, both small and large MiaPaCa02 subcutaneous tumors showed statistically significant growth inhibition. Conversely, there was no significant difference in tumor growth between large and small tumors. Both computational and xenograft models demonstrated higher maximum tumor temperatures for large tumors compared to small tumors. Computational modeling demonstrates that pulsed AMF can minimize nonspecific eddy current heating. Conclusions: MNPH provides an advantage to treat large tumors because the MION dose can be adjusted to increase power. Pulsed AMF, with adjusted treatment time, can enhance MNPH in challenging cases such as low MION dose in the target tissue and/or large patients by minimizing nonspecific eddy current heating without sacrificing thermal dose to the target. Nanoparticle heterogeneity in tumors remains a challenge for continued research. |
Databáze: | OpenAIRE |
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