Is the time interval between surgery and radiotherapy important in operable nonsmall cell lung cancer? A retrospective analysis of 340 cases
| Autor: | michael Ehnert, H. P. Heilmann, H. Bünemann, Florian Würschmidt |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms Time Factors medicine.medical_treatment Pulmonary Fibrosis Subgroup analysis Sex Factors Carcinoma Non-Small-Cell Lung medicine Carcinoma Odds Ratio Humans Radiology Nuclear Medicine and imaging Survival rate Aged Neoplasm Staging Retrospective Studies Univariate analysis Radiation business.industry Retrospective cohort study Radiotherapy Dosage Middle Aged medicine.disease Prognosis Combined Modality Therapy Surgery Log-rank test Radiation therapy Radiation Pneumonitis Survival Rate Oncology Adenocarcinoma Female business Cell Division |
| Zdroj: | International journal of radiation oncology, biology, physics. 39(3) |
| ISSN: | 0360-3016 |
| Popis: | Purpose: To evaluate the influence of prognostic factors in postoperative radiotherapy of NSCLC with special emphasis on the time interval between surgery and start of radiotherapy. Methods and Materials: Between January 1976 and December 1993, 340 cases were treated and retrospectively analyzed meeting the following criteria: complete follow-up; complete staging information including pathological confirmation of resection status; maximum interval between surgery (SX) and radiotherapy (RT) of 12 weeks (median 36 days, range 18 to 84 days); minimum dose of 50 Gy (R0), and maximum dose of 70 Gy (R2). Two hundred thirty patients (68%) had N2 disease; 228 patients were completely resected (R0). One hundred six (31%) had adenocarcinoma, 172 (51%) squamous cell carcinoma. Results: In univariate analysis, Karnofsky performance status (90+ >60-80%; p = 0.019 log rank), resection status stratified for nodal disease (R+ |
| Databáze: | OpenAIRE |
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