| Autor: |
Michael R. Speicher, Jochen B. Geigl, Thomas Bauernhofer, Sabine Riethdorf, Klaus Pantel, Hellmut Samonigg, Heinz Sill, Florian Eisner, Gerald Höfler, Carolin Lackner, Oliver Mauermann, Julie Waldispuehl-Geigl, Sigurd Lax, Eva Maria Hoffmann, Peter Ulz, Martin Pichler, Christin Gasch, Martina Auer, Ellen Heitzer |
| Rok vydání: |
2023 |
| Popis: |
PDF file - 868K, Ratio bin distributions for CTC12 (a) and CTC03 (b) from patient #6. The large bin 13 peak indicates the frequency of oligonucleotides with balanced ratio values. The bins to the right of 13 represent the bins for oligonucleotides with deleted, the bins to the left oligonucleotides with increased values. (a) In CTC12 only one of the bins for deleted values was increased (i.e. bin 15), suggesting that this cell is diploid. In a diploid cell the log2 ratio for balanced values ranges from 0.295 to -0.293 and therefore extends to bins adjacent to 13, which is reflected by the small increases in the bins 12 and 14. The peaks at bins 11 and 12 reflect trisomies (i.e. a 3:2 ratio or an integer copy number of 3), the peak at 9 indicates tetrasomies (i.e. 4:2) or 4 copies). (b) CTC03 had clearly more discrete deleted copy number states visible at bins 15 to 18, suggesting that this cell is tetraploid. In a tetraploid cell the log2 ratio range for balanced values is narrower (i.e. 0.161 to -0.208) as in a diploid cell, which is reflected in the almost empty bins 12 and 14. Bin 15 represents oligonucleotides with ratio values translating to 3 copies, bins 16 and 17 to two copies and bin 18 to one copy. Bin 10 represents 5 copies, bins 8 and 9 six copies, bin 7 seven copies, and bin 4 eight copies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
