Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice
| Autor: | Tamara G. Amstislavskaya, Nina K. Popova, E. G. Kuznetsova, V. V. Bulygina, Marina A. Tibeikina |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Agonist Blood level medicine.medical_specialty medicine.drug_class medicine.medical_treatment Intraperitoneal injection Anxiety Motor Activity Pharmacology Anxiolytic General Biochemistry Genetics and Molecular Biology Mice chemistry.chemical_compound Corticosterone Internal medicine medicine Animals Motor activity Receptor MK-212 Behavior Animal Chemistry General Medicine Serotonin Receptor Agonists Endocrinology Depression Chemical Pyrazines Mice Inbred CBA Serotonin 5-HT2 Receptor Agonists |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 142:594-597 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-006-0427-2 |
| Popis: | A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low doses of 0.1 and 0.2 mg/kg, the agonist reduced anxiety, but had no effect on motor activity. It is hypothesized that low doses of MK-212 exhibited anxiolytic activity in mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink