Disseminated histoplasmosis in primary Sjögren syndrome: A case report
| Autor: | Wuqiong Zhang, Yin-Yin Xie, Wei Jiang, Zhi-Tao Cui, Ying-Ying Cheng, Hongmei Meng, Jia-Ai Li, Zhong-Hua Du, Bin Gao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Case Report General Medicine Sjögren syndrome medicine.disease Pancytopenia Dermatology Histoplasmosis stomatognathic diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Respiratory failure Disseminated histoplasmosis 030220 oncology & carcinogenesis medicine 030211 gastroenterology & hepatology Bone marrow business Primary Sjögren Syndrome Dimorphic fungus |
| Popis: | Background Sjogren syndrome (SS) is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. And histoplasmosis is an invasive mycosis caused by the saprophytic dimorphic fungus H. capsulatum. In patients with primary SS (PSS), disseminated histoplasmosis (DH) is extremely rare. Case summary We report a 37-year-old female patient admitted to our hospital with exacerbating fatigue, somnolence, and pancytopenia as the main symptoms. She was eventually diagnosed with DH based on pancytopenia, splenomegaly, and findings of bone marrow smears. The atypical clinical symptoms made the diagnosis process more tortuous. Unfortunately, she died of respiratory failure on the day the diagnosis was confirmed. Conclusion We present a rare and interesting case of DH in a PSS patient. This case updates the geographic distribution of histoplasmosis in China, and expands the clinical manifestations of DH in PSS, highlighting the significance of constantly improving the understanding of PSS with DH. |
| Databáze: | OpenAIRE |
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