Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction
| Autor: | Hui-Dong Wang, Wen Jiang, Jun-Min Yu, Yina Zhang, Xiao-Bo Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Cancer Research medicine.medical_specialty Angiogenesis medicine.medical_treatment Basic fibroblast growth factor Intraperitoneal injection Drug Evaluation Preclinical Myocardial Infarction Gene Expression Neovascularization Physiologic Biochemistry Neovascularization chemistry.chemical_compound angiogenesis Internal medicine Genetics medicine Animals Myocardial infarction astragaloside Rats Wistar Molecular Biology Oncogene vascular endothelial growth factor business.industry Myocardium Articles basic fibroblast growth factor Saponins medicine.disease Coronary Vessels Triterpenes Vascular endothelial growth factor Vascular endothelial growth factor A Disease Models Animal Endocrinology Oncology chemistry Microvessels cardiovascular system Molecular Medicine Angiogenesis Inducing Agents Fibroblast Growth Factor 2 medicine.symptom business |
| Zdroj: | Molecular Medicine Reports |
| ISSN: | 1791-3004 1791-2997 |
| Popis: | The aim of the present study was to evaluate the effect of astragalosides (ASTs) on angiogenesis, as well as the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) following myocardial infarction (MI). MI was induced in rats by ligation of the left coronary artery. Twenty‑four hours after surgery, the rats were divided into low‑dose, high‑dose, control and sham surgery groups (n=8 per group). The low‑ and high‑dose groups were treated with ASTs (2.5 and 10 mg/kg/day, respectively, via intraperitoneal injection), while, the control and sham surgery group rats received saline. Serum levels, and mRNA and protein expression levels of VEGF and bFGF, as well as the microvessel density (MVD) were determined four weeks post‑treatment. Twenty‑four hours post‑surgery, VEGF and bFGF serum levels were observed to be comparable between the groups; while at four weeks, the VEGF and bFGF levels were higher in the AST‑treated rats (P |
| Databáze: | OpenAIRE |
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