Lower sulfurtransferase detoxification rates of cyanide in konzo—A tropical spastic paralysis linked to cassava cyanogenic poisoning
| Autor: | L. A. Okitundu, Diane D. Stadler, William E. Lambert, K. P. Kayembe, Daniel Tshala-Katumbay, D. Mumba Ngoyi, K. J. Kambale, Michael J. Boivin, N. H. Sadiki, D. L. Yandju, L. G. Mvumbi, E. R. Ali, Gerry R. Boss, Michael R. Lasarev, J. P. Banea |
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| Rok vydání: | 2017 |
| Předmět: |
Male
endocrine system Adolescent Cyanide Motor Disorders Physiology Urine Rhodanese Toxicology Article Statistics Nonparametric chemistry.chemical_compound 0404 agricultural biotechnology Detoxification Nitriles Humans Medicine Child Retrospective Studies Konzo Analysis of Variance Cyanides business.industry General Neuroscience Neurotoxicity Case-control study 04 agricultural and veterinary sciences medicine.disease 040401 food science Paraparesis Tropical Spastic chemistry Biochemistry Case-Control Studies Child Preschool Sulfurtransferases Female Analysis of variance Cognition Disorders business |
| Zdroj: | NeuroToxicology. 59:256-262 |
| ISSN: | 0161-813X |
| DOI: | 10.1016/j.neuro.2016.05.016 |
| Popis: | Using a matched case-control design, we sought to determine whether the odds of konzo, a distinct spastic paraparesis associated with food (cassava) cyanogenic exposure in the tropics, were associated with lower cyanide detoxification rates (CDR) and malnutrition. Children with konzo (N= 122, 5–17 years of age) were age- and sex-matched with presumably healthy controls (N = 87) and assessed for motor and cognition performances, cyanogenic exposure, nutritional status, and cyanide detoxification rates (CDR). Cyanogenic exposure was ascertained by thiocyanate (SCN) concentrations in plasma (P-SCN) and urine (U-SCN). Children with a height-for-age z-score (HAZNCHS) < −2 were classified as nutritionally stunted. CDR was measured as time required to convert cyanide to SCN, and expressed as ms/μmol SCN/mg protein or as mmolSCN/ml plasma/min. Mean (SD) U-SCN in children with konzo was 521.9 (353.6) μmol/l and was, significantly higher than 384.6 (223.7) μmol/l in those without konzo. Conditional regression analysis of data for age- and sex- matched case-control pairs showed that konzo was associated with stunting (OR: 5.8; 95% CI: 2.7–12.8; p |
| Databáze: | OpenAIRE |
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