Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection
| Autor: | Marta Giovanetti, Alessandro Russo, Massimo Ciccozzi, Paolo Vassalini, Gabriella d'Ettorre, Claudio Maria Mastroianni, Ornella Spagnolello, Silvia Fabris, Gabriella De Girolamo, Letizia Santinelli, Giancarlo Ceccarelli, Silvia Angeletti, Claudia Pinacchio, Giuseppe Pietro Innocenti |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 030106 microbiology Review Pulmonary function testing law.invention 03 medical and health sciences Probiotic 0302 clinical medicine Immune system Systemic cytokine storm law Drug Discovery Gut-lung axis medicine Humans Pharmacology (medical) Microbiome COVID-19 dysbiosis gut-lung axis probiotics systemic cytokine storm Pharmacology business.industry SARS-CoV-2 Probiotics General Medicine medicine.disease Gastrointestinal Microbiome Pneumonia Infectious Diseases Oncology 030220 oncology & carcinogenesis Immunology Dietary Supplements Dysbiosis business Bacteriotherapy |
| Zdroj: | Chemotherapy |
| ISSN: | 1421-9794 |
| Popis: | Respiratory and gastrointestinal symptoms are the predominant clinical manifestations of the coronavirus disease 2019 (COVID-19). Infecting intestinal epithelial cells, the severe acute respiratory syndrome coronavirus-2 may impact on host’s microbiota and gut inflammation. It is well established that an imbalanced intestinal microbiome can affect pulmonary function, modulating the host immune response (“gut-lung axis”). While effective vaccines and targeted drugs are being tested, alternative pathophysiology-based options to prevent and treat COVID-19 infection must be considered on top of the limited evidence-based therapy currently available. Addressing intestinal dysbiosis with a probiotic supplement may, therefore, be a sensible option to be evaluated, in addition to current best available medical treatments. Herein, we summed up pathophysiologic assumptions and current evidence regarding bacteriotherapy administration in preventing and treating COVID-19 pneumonia. |
| Databáze: | OpenAIRE |
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