Clinical spectrum of urine cultures positive for ESBL-producing Escherichia coli in hospitalized patients and impact on antibiotic use

Autor: R, Lepeule, V, Leflon-Guibout, D, Vanjak, J-R, Zahar, M, Lafaurie, C, Besson, A, Lefort, J -R, Zahar
Rok vydání: 2014
Předmět:
Male
Carbapenem
Antibiotics
Inappropriate Prescribing
Urine
medicine.disease_cause
Substrate Specificity
Risk Factors
polycyclic compounds
Medicine
Prospective Studies
Child
Escherichia coli Infections
Aged
80 and over
Cross Infection
medicine.diagnostic_test
Middle Aged
Anti-Bacterial Agents
Infectious Diseases
Child
Preschool
Urinary Tract Infections
Female
medicine.drug
Adult
Paris
medicine.medical_specialty
Adolescent
Bacteriuria
Urinalysis
medicine.drug_class
Urinary system
Esbl production
Microbial Sensitivity Tests
beta-Lactam Resistance
beta-Lactamases
Microbiology
Young Adult
Bacterial Proteins
Internal medicine
Escherichia coli
Humans
Antibiotic use
Aged
business.industry
Infant
Newborn
Infant
biochemical phenomena
metabolism
and nutrition
bacterial infections and mycoses
Catheter-Related Infections
bacteria
business
Zdroj: Médecine et Maladies Infectieuses. 44:530-534
ISSN: 0399-077X
DOI: 10.1016/j.medmal.2014.09.004
Popis: Objective We wanted to describe the clinical features associated with urinalysis positive for ESBL-producing Escherichia coli and their impact on antibiotic use. Methods We performed a prospective observational study in 13 French hospitals of the Paris area for 3 consecutive months. We included all patients with urine cultures positive for ESBL-producing E . coli . Results One hundred and seventeen of the 218 patients (54%) presented with asymptomatic bacteriuria, 31 (14%) with cystitis, and 70 (32%) with a parenchymal infection. Nineteen patients with asymptomatic bacteriuria (16%) received antibiotics. Forty-one with parenchymal infections (59%) received a carbapenem. A carbapenem alternative could have been used in every patient treated with a carbapenem, according to antibiotic susceptibility testing results. Conclusions Urinary tract infections accounted for 46% of E . coli ESBL positive urinalysis. Fifty percent of parenchymal infections were treated with a carbapenem.
Databáze: OpenAIRE
Externí odkaz: