Two pairs of phenolic enantiomers from the leaves of Eucommia ulmoides Oliver
| Autor: | Xiumei Gao, Li-Qin Ding, Jian-Kun Yan, Feng Qiu, Paul Owusu Donkor, Xu-Liu Shi |
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| Rok vydání: | 2018 |
| Předmět: |
Resolution (mass spectrometry)
ved/biology.organism_classification_rank.species Eucommia ulmoides Plant Science 01 natural sciences Biochemistry Analytical Chemistry Phenols Humans Chromatography Molecular Structure biology 010405 organic chemistry ved/biology Chemistry Eucommiaceae Spectrum Analysis Organic Chemistry Stereoisomerism Hep G2 Cells biology.organism_classification 0104 chemical sciences Plant Leaves Hep G2 010404 medicinal & biomolecular chemistry Eucommia Drug Screening Assays Antitumor Enantiomer |
| Zdroj: | Natural Product Research. 33:1162-1168 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Two pairs of new phenolic enantiomers, (+)-eucophenolic A (1a), (-)-eucophenolic B (1b), (-)-eucophenolic C (2a), (+)-eucophenolic D (2b) were isolated from the leaves of Eucommia ulmodies Oliver by chiral enantiomeric resolution. Their structures were elucidated based on extensive spectroscopic analysis. The absolute configurations of 1a/1b and 2a/2b were determined by empirical method and the calculated ECD and OR. All compounds were tested for Hep G2 tumour cell lines. However, no compounds showed potential cytotoxic activities against Hep G2 in vitro. |
| Databáze: | OpenAIRE |
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