LSD Produces Conditioned Place Preference in Male But Not Female Fawn Hooded Rats
| Autor: | Susanne M. Meehan, Martin D. Schechter |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Hallucinogen medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Toxicology Serotonergic Choice Behavior Biochemistry Developmental psychology Behavioral Neuroscience Internal medicine medicine Animals Humans Saline Biological Psychiatry Lysergic acid diethylamide Pharmacology Analysis of Variance Sex Characteristics Rats Inbred Strains Rat strain Conditioned place preference Rats Lysergic Acid Diethylamide Endocrinology Conditioning Operant Female Serotonin Cues Psychology medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 59:105-108 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/s0091-3057(97)00391-2 |
| Popis: | Male and female Fawn Hooded rats were examined for conditioned place preference (CPP) or aversion (CPA) to lysergic acid diethylamide (LSD). Using a biased design, experimental animals were trained with LSD (0.2 mg/kg, I.P.) administered in conjunction with confinement in either the preferred or nonpreferred location. Control animals received confinement in both locations after administration of saline. Results indicated that rats administered LSD while sequestered in the nonpreferred location spent more time in that location during a nondrug test. This effect, indicative of a conditioned place preference, was exhibited only in male animals. Results are discussed in terms of potential sex differences that may mediate serotonergic sensitivity in the Fawn Hooded rat strain. |
| Databáze: | OpenAIRE |
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