Short contact with nickel causes allergic contact dermatitis: an experimental study
| Autor: | Jacob P. Thyssen, C. R. Johnsen, Malin G. Ahlström, Anneli Julander, Klara Midander, Torkil Menné, Carola Lidén, Jeanne D. Johansen |
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| Rok vydání: | 2018 |
| Předmět: |
inorganic chemicals
0301 basic medicine Adult Male medicine.medical_specialty Time Factors chemistry.chemical_element Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Forearm Nickel Occlusion otorhinolaryngologic diseases medicine Humans Allergic contact dermatitis Earlobe Skin Tests integumentary system business.industry Sodium Dodecyl Sulfate Blood flow Laser Doppler velocimetry Allergens Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure Human Experimentation chemistry Dermatitis Allergic Contact Irritants Forearm skin Female business Aluminum |
| Zdroj: | The British journal of dermatology. 179(5) |
| ISSN: | 1365-2133 |
| Popis: | Background Knowledge about the required duration of exposure for elicitation of allergic nickel dermatitis in nickel-allergic individuals is limited. However, it often has been proposed that short skin contact is safe. Objectives To examine whether repeated skin contact with nickel over short time periods (3 × 10 min) can elicit allergic nickel dermatitis. Methods Sixteen nickel-allergic adults and 10 controls were exposed to, respectively, nickel- and aluminium-containing discs on each volar forearm and on each earlobe for 3 × 10 min. One arm was pretreated for 24 h with sodium lauryl sulfate (SLS) 0·5% under occlusion before exposure. One aluminium and one nickel exposure site were clinically evaluated, and blood flow was measured with laser Doppler flowmetry at day 2 and day 4. Results Ten of 16 (63%) nickel-allergic participants developed allergic nickel dermatitis on SLS-pretreated arm skin and three of 16 (19%) developed it on normal skin on the earlobe. On the SLS-pretreated arms of nickel-allergic participants, blood flow increased significantly more on the nickel-exposed skin than on the aluminium-exposed skin on days 2 and 4. No change in clinical reactivity or blood flow was found on normal forearm skin in nickel-allergic participants or on any skin in controls. Conclusions This experimental study showed that relatively short repeated skin contact (3 × 10 min) with metallic nickel elicits allergic nickel dermatitis in irritated skin and at sites with previous dermatitis. The results support the restrictions in current nickel regulation. |
| Databáze: | OpenAIRE |
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