Dysfunctional cortical inhibition in adult ADHD: neural correlates in auditory event-related potentials
| Autor: | Michael Rösler, Gabriele Steidl, Farah I. Corona-Strauss, Ernesto Gonzalez-Trejo, Tanja Teuber, Wolfgang Retz, J. K. Schubert, Daniel J. Strauss |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Auditory event Dysfunctional family Objective assessment Developmental psychology Young Adult Event-related potential Humans Cerebral Cortex Neural correlates of consciousness General Neuroscience Electroencephalography Neural Inhibition Signal Processing Computer-Assisted Middle Aged Acoustic Stimulation Attention Deficit Disorder with Hyperactivity Auditory Perception Evoked Potentials Auditory Intracortical inhibition Female Objective information Cortical inhibition Psychology Artifacts Neuroscience |
| Zdroj: | Journal of neuroscience methods. 235 |
| ISSN: | 1872-678X |
| Popis: | In recent times, the relevance of an accurate diagnosis of attention-deficit/hyperactivity disorder (ADHD) in adults has been the focus of several studies. No longer considered a pathology exclusive to children and adolescents, and taking into account its social implications, developing enhanced support tools for the current diagnostic procedure becomes a priority. Here we present a method for the objective assessment of ADHD in adults using chirp-evoked, paired auditory late responses (ALRs) combined with a two-dimensional ALR denoising scheme to extract correlates of intracortical inhibition. Our method allows for an effective single-sweep denoising, thus requiring less trials to obtain recognizable physiological features, useful as pointers of cortical impairment. Results allow an optimized diagnosis, reduction of data loss and acquisition time; moreover, they do not account exclusively for critical elements within clinical evaluations, but also allow studying the pathophysiology of the condition by providing objective information regarding impaired cortical functions. |
| Databáze: | OpenAIRE |
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