Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

Autor:	Michael Hertl, Helga Kahlert, Carolien A. M. Koeleman, Alexandra Epp, Mattias Collin, Timo Gemoll, Dominique Braumann, Arnd Petersen, Gina-Maria Lilienthal, Frank Petersen, Manfred Wuhrer, Fred D. Finkelman, Marc Ehlers, Josephine Bitterling, Simon Eschweiler, Andreas Nandy, Robina Thurmann, Christine Engellenner, Ashley Hall, Wolfgang Pfützner, Johann Rahmöller, Jens K. Habermann, Kelley W. Moremen, Richard T. Strait, Juliane Hobusch, Uta Jappe, Janina Petry, Alexei Leliavski, Yannic C. Bartsch, Véronique Blanchard, Suzanne C. Morris, Christian Möbs
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine Glycosylation Immunology macromolecular substances Immunoglobulin E medicine.disease_cause Article Immunomodulation 03 medical and health sciences chemistry.chemical_compound Allergen medicine Hypersensitivity Immunology and Allergy Humans biology Chemistry Extramural 030104 developmental biology Post translational Immunoglobulin G Protein processing biology.protein Antibody Protein Processing Post-Translational
Zdroj:	Journal of Allergy and Clinical Immunology, 141(1), 399-402 Journal of Allergy and Clinical Immunology
Popis:	In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9b456854d555d1d2d8b1849f1ed796 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758435/pdf/nihms893666.pdf Zobrazit plný text záznamu