MRI Diagnosis of NF-1 in Children Without Café-Au-Lait Skin Lesions
| Autor: | Joel S. Glaser, Richard G. Curless, Norman J. Shatz, Michael Siatkowski |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Pathology Neurofibromatosis 1 Adolescent Optic glioma Developmental Neuroscience Glioma Café au lait spot medicine Humans Cranial nerve disease Neurofibromatosis Child Pigmentation disorder medicine.diagnostic_test business.industry Cafe-au-Lait Spots Incidence Optic Nerve Neoplasms Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Neurology Child Preschool Pediatrics Perinatology and Child Health Optic nerve Neurology (clinical) Radiology medicine.symptom business |
| Zdroj: | Pediatric Neurology. 18:269-271 |
| ISSN: | 0887-8994 |
| DOI: | 10.1016/s0887-8994(97)00189-6 |
| Popis: | Three of ten children with optic gliomas satisfy the 1987 National Institutes of Health consensus criteria for neurofibromatosis type 1 (NF-1). The diagnosis in these cases is based on the presence of café-au-lait skin lesions in addition to the optic glioma. Two children without skin lesions have typical findings on magnetic resonance imaging (MRI) that also suggest a diagnosis of NF-1. A review of 281 NF-1 children with brain MRI results demonstrates the presence of these abnormalities in 57% of the cases. It is suggested that this MRI abnormality is sufficiently specific to add this feature to the list of diagnostic criteria. When MRI findings are present in a child with optic glioma and without skin lesions, counseling should be given for NF-1. It is noteworthy that these typical MRI findings in NF-1 are less common in adulthood, apparently because of spontaneous resolution. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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