Association of grip strength with cardiovascular risk markers
| Autor: | Cédric Gubelmann, Pedro Marques-Vidal, Peter Vollenweider |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Muscle Strength Dynamometer Homocysteine Epidemiology Cross-sectional study 030204 cardiovascular system & hematology Severity of Illness Index Body Mass Index Grip strength chemistry.chemical_compound 0302 clinical medicine Surveys and Questionnaires Prevalence 030212 general & internal medicine education.field_of_study Hand Strength Smoking Age Factors Middle Aged Cardiovascular Diseases Hypertension Female Aged Biomarkers/analysis Cardiovascular Diseases/diagnosis Cardiovascular Diseases/epidemiology Cross-Sectional Studies Hand Strength/physiology Health Surveys Humans Hypercholesterolemia/diagnosis Hypercholesterolemia/epidemiology Hypertension/epidemiology Linear Models Multivariate Analysis Obesity/diagnosis Obesity/epidemiology Risk Assessment Sex Factors Smoking/epidemiology Switzerland/epidemiology Switzerland anthropometry blood pressure glucose inflammation lipids population-based study Cardiology and Cardiovascular Medicine medicine.medical_specialty Hypercholesterolemia Population 03 medical and health sciences Internal medicine medicine Obesity education business.industry Anthropometry Blood pressure chemistry Physical therapy business Body mass index Biomarkers |
| Zdroj: | European journal of preventive cardiology, vol. 24, no. 5, pp. 514-521 Europe PubMed Central |
| Popis: | Background Mechanisms underlying the association between grip strength and cardiovascular mortality are poorly understood. We aimed to assess the association of grip strength with a panel of cardiovascular risk markers. Design The study was based on a cross-sectional analysis of 3468 adults aged 50-75 years (1891 women) from a population-based sample in Lausanne, Switzerland. Methods Grip strength was measured using a hydraulic hand dynamometer. Cardiovascular risk markers included anthropometry, blood pressure, lipids, glucose, adiposity, inflammatory and other metabolic markers. Results In both genders, grip strength was negatively associated with fat mass (Pearson correlation coefficient: women: -0.170, men: -0.198), systolic blood pressure (women: -0.096, men: -0.074), fasting glucose (women: -0.048, men: -0.071), log-transformed leptin (women: -0.074, men: -0.065), log-transformed high-sensitivity C-reactive protein (women: -0.101, men: -0.079) and log-transformed homocysteine (women: -0.109, men: -0.060). In men, grip strength was also positively associated with diastolic blood pressure (0.068), total (0.106) and low density lipoprotein-cholesterol (0.082), and negatively associated with interleukin-6 (-0.071); in women, grip strength was negatively associated with triglycerides (-0.064) and uric acid (-0.059). After multivariate adjustment, grip strength was negatively associated with waist circumference (change per 5 kg increase in grip strength: -0.82 cm in women and -0.77 cm in men), fat mass (-0.56% in women; -0.27% in men) and high-sensitivity C-reactive protein (-6.8% in women; -3.2% in men) in both genders, and with body mass index (0.22 kg/m javax.xml.bind.JAXBElement@165be361 ) and leptin (-2.7%) in men. Conclusion Grip strength shows only moderate associations with cardiovascular risk markers. The effect of muscle strength as measured by grip strength on cardiovascular disease does not seem to be mediated by cardiovascular risk markers. |
| Databáze: | OpenAIRE |
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