Alkaline phosphatase inhibition by a series of pyrido[2,1-b]quinazolines: a possible relationship with cromolyn-like antiallergy activity
| Autor: | Charles F. Schwender, Brooks R. Sunday, Victoria L. Decker |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Chemical Phenomena
Placenta In Vitro Techniques Pharmacology Inhibitory postsynaptic potential Pregnancy Cromolyn Sodium Drug Discovery Hypersensitivity Leukocytes Animals Humans Potency Clinical efficacy chemistry.chemical_classification Voltage-dependent calcium channel musculoskeletal neural and ocular physiology Passive Cutaneous Anaphylaxis Alkaline Phosphatase Rats Chemistry Enzyme chemistry Antiallergic agent Quinazolines Molecular Medicine Alkaline phosphatase Female |
| Zdroj: | Journal of Medicinal Chemistry. 25:742-745 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | Several known antiallergic agents, including cromolyn sodium and a series of pyrido[2,1-b]quinazolines, inhibit human alkaline phosphatase (ALP), a membranal enzyme associated with calcium uptake in certain tissues. A comparison of ALP and rat passive cutaneous anaphylaxis (PCA) inhibition indicates that PCA inhibition may be associated with drug-ALP interaction, since ALP inhibition potency parallels PCA inhibitory activity. The unpredictability of the PCA test toward clinical efficacy could in part be related to the uncompetitive nature of these inhibitors. The results also suggest that alkaline phosphatase may be a component of membranal calcium channels. |
| Databáze: | OpenAIRE |
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