Brainstem nucleus incertus controls contextual memory formation
| Autor: | Panna Hegedüs, Balázs Pósfai, Viktor Sebestyén Varga, Virág T. Takács, Tamás F. Freund, Dániel Schlingloff, Attila I. Gulyás, Andor Domonkos, Rita Nyilas, James B. Priestley, Attila Losonczy, Katalin E. Sos, Gábor Nyiri, Andrew L. Gundlach, András Szőnyi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Hippocampus Engram Optogenetics Hippocampal formation Memory and Learning Tests Article Mice 03 medical and health sciences 0302 clinical medicine Interneurons Animals GABAergic Neurons Theta Rhythm 030304 developmental biology 0303 health sciences Multidisciplinary Chemistry Pyramidal Cells Association Learning Neural Inhibition Nucleus Incertus Mice Inbred C57BL Excitatory postsynaptic potential GABAergic Raphe Nuclei Female Brainstem Somatostatin Neuroscience 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | Science |
| Popis: | What inhibits the inhibitors? In the hippocampus, each memory trace is encoded by a specific subset of pyramidal cells. The other pyramidal cells must be actively excluded from the memory encoding process by inhibition, which is done by selective dendrite-targeting interneurons. Szőnyi et al. found that γ-aminobutyric acid–releasing (GABAergic) cells located in a small region in the brain stem called the nucleus incertus project to the hippocampus. The nucleus incertus again is innervated by several regions that respond to salient stimuli. Its GABAergic cells preferentially inhibit the dendrite-targeting interneurons in the hippocampus. The nucleus incertus is thus a central mediator between brain regions that are highly responsive to salient stimuli and the hippocampal circuitry involved in memory formation. Science , this issue p. eaaw0445 |
| Databáze: | OpenAIRE |
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