The neurite growth inhibitory protein Nogo-A has diverse roles in adhesion and migration
| Autor: | Andre Schmandke, Antonio Schmandke, Martin E. Schwab, Alice C. Mosberger, Zeliha Celen |
|---|---|
| Přispěvatelé: | University of Zurich, Schwab, Martin E |
| Rok vydání: | 2013 |
| Předmět: |
Cerebellum
Neurite Nogo Proteins Regulator 2804 Cellular and Molecular Neuroscience 610 Medicine & health Biology Inhibitory postsynaptic potential 1307 Cell Biology 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cell Movement mental disorders Cell Adhesion Neurites medicine Humans Cell adhesion Letter to the Editor 030304 developmental biology 0303 health sciences 10242 Brain Research Institute Cell growth Membrane Proteins Cell Biology Granule cell Cell biology CXCL3 medicine.anatomical_structure 570 Life sciences biology Myelin Proteins psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | CELL ADHESION & MIGRATION Cell Adhesion & Migration |
| DOI: | 10.4161/cam.27164 |
| Popis: | Next to its well-established role as a myelin-associated neurite growth-inhibitory protein, Nogo-A more recently has emerged as an important modulator of adhesion and migration. However, Nogo-A’s function in adhesion and migration is diverse and strongly dependent on a complex orchestration of cell-intrinsic as well as extrinsic factors. In this letter we summarize the current knowledge on Nogo-A’s role in adhesive and migratory mechanisms. Additionally, we revisit an earlier hypothesis concerning a putative role for Nogo-A as regulator of early post-natal cerebellar granule cell migration. Pulse labeling of proliferating cerebellar granule neurons in early postnatal wild-type and Nogo-A-null mice enabled us to follow their migration dynamics over multiple days. Neither migration speed, nor cell proliferation, or layer area sizes were influenced by Nogo-A deletion, hence suggesting another role for early postnatal Nogo-A expression in the premigratory zone of the external granule layer. |
| Databáze: | OpenAIRE |
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