Intravitreal Administration of Antiviral Agents in Silicone Oil-Filled Human Eyes
| Autor: | Alexander Rubowitz, Sarah Sella, Amit Meshi, Sharon Armarnik, Asaf Friehmann, Raz Gepstein, Ehud I. Assia |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Ganciclovir
Foscarnet medicine.medical_specialty business.industry Progressive outer retinal necrosis Retinitis Intravitreal administration medicine.disease Surgery medicine.infectious_disease 03 medical and health sciences Ophthalmology 0302 clinical medicine Adjunctive treatment 030221 ophthalmology & optometry medicine Tamponade Acute retinal necrosis business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Ophthalmology. Retina. 1(4) |
| ISSN: | 2468-6530 |
| Popis: | Purpose To report our experience with intra-silicone oil (SO) injection of antiviral agents for treatment of viral retinitis and to review the relevant literature. Design Two case reports and a literature review. Participants Two patients with viral retinitis and SO tamponade. Methods Two patients with viral retinitis were treated with intravitreal injections of low-dose ganciclovir (2 mg/0.05 ml), foscarnet (1.2 mg/0.05 ml), or both after retinal detachment repair with SO tamponade, in addition to systemic antiviral therapy from 2014 through 2015. The literature on the use of intraocular antiviral agents in the setting of SO vitreous substitute was reviewed. Main Outcome Measures Clinical outcomes after administration of intra-SO antiviral therapy. Results A patient with progressive outer retinal necrosis received 5 intra-SO injections of low-dose ganciclovir and foscarnet after surgery over 6 weeks. Another patient with acute retinal necrosis received weekly low-dose foscarnet injections into his SO-filled eye for 8 weeks after surgery. Significant retinitis regression with long-term retinitis control was achieved in both patients throughout follow-up. No articles reporting the administration of soluble antiviral agents into an SO-filled human eye were identified. Conclusions Our preliminary findings indicate that administration of low-dose ganciclovir and foscarnet into an SO-filled eye may be used as adjunctive treatment for viral retinitis. Further studies are needed to confirm these results. |
| Databáze: | OpenAIRE |
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