A unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses
| Autor: | Masayuki Fukata, Jinhee Hyun, Saravana Kanagavelu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Toll-like receptor
Innate immune system Immunology Toll-Like Receptors Host Defense Mechanism Bacterial Infections Biology Microbiology Immunity Innate Article Cell biology Adaptor Proteins Vesicular Transport Infectious Diseases Immune system Immunity TRIF Interferon Virus Diseases Host-Pathogen Interactions medicine Humans Multipotentiality medicine.drug |
| Zdroj: | Microbes and Infection |
| ISSN: | 1286-4579 |
| DOI: | 10.1016/j.micinf.2012.10.011 |
| Popis: | Both anti-viral and anti-bacterial host defense mechanisms involve TRIF signaling. TRIF provides early clearance of pathogens and coordination of a local inflammatory ensemble through an interferon cascade, while it may trigger organ damage. The multipotentiality of TRIF-mediated immune machinery may direct the fate of our continuous battle with microbes. |
| Databáze: | OpenAIRE |
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