Treatment of infantile fibrosarcoma associated to an abdominal aortic aneurysm with larotrectinib: a case report

Autor:	Ana Sastre Urgelles, Felipe Gómez Martín, Eduardo Alonso Gamarra, Juan Carlos López Gutiérrez, Leopoldo Martinez, Rita María Regojo Zapata, José Juan Pozo Kreilinger, Antonio Pérez-Martínez, Elena Marín Manzano, Diego Plaza López de Sabando, Ana María Sánchez Torres, María Dolores Corral Sánchez, Víctor Galán Gómez, Pedro Rubio Aparicio, Luis Gonzalez Del Valle, Eugenia Antolín Alvarado
Rok vydání:	2021
Předmět:	Fibrosarcoma 03 medical and health sciences Aortic aneurysm 0302 clinical medicine Growth factor receptor Medicine Humans Receptor Protein Kinase Inhibitors business.industry Infant Newborn Infant Hematology medicine.disease Tropomyosin Abdominal aortic aneurysm Pyrimidines Oncology 030220 oncology & carcinogenesis Trk receptor Abdominal Neoplasms Pediatrics Perinatology and Child Health Cancer research Pyrazoles Female Infantile Fibrosarcoma business Tyrosine kinase 030215 immunology Aortic Aneurysm Abdominal
Zdroj:	Pediatric hematology and oncology. 38(5)
ISSN:	1521-0669
Popis:	Infantile fibrosarcoma (IFS) is a rare pediatric tumor which often presents the ETV6-NTRK3 gene fusion. NTRK3 encodes the neurotrophin-3 growth factor receptor tyrosine kinase, a druggable therapeutic target. Selective tropomyosin receptor kinase (TRK) inhibitors, such as larotrectinib, have shown efficacy and safety in the treatment of IFS. We report a case of an abdominal IFS diagnosed in a newborn associated with an aortic aneurysm that was successfully treated with larotrectinib without relevant adverse effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8c4478266dae6e871b9de4cd2a3b9a https://pubmed.ncbi.nlm.nih.gov/33622165 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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