Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo
| Autor: | Natalia Benetti, Quentin Gouil, Andres Tapia del Fierro, Tamara Beck, Kelsey Breslin, Andrew Keniry, Edwina McGlinn, Marnie E. Blewitt |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Multidisciplinary
Chromosomal Proteins Non-Histone Genes Homeobox General Physics and Astronomy Gene Expression Gene Expression Regulation Developmental Polycomb-Group Proteins General Chemistry Embryo Mammalian General Biochemistry Genetics and Molecular Biology Chromatin Mice Pregnancy Animals Female |
| Zdroj: | Nature communications. 13(1) |
| ISSN: | 2041-1723 |
| Popis: | Parents transmit genetic and epigenetic information to their offspring. Maternal effect genes regulate the offspring epigenome to ensure normal development. Here we report that the epigenetic regulator SMCHD1 has a maternal effect on Hox gene expression and skeletal patterning. Maternal SMCHD1, present in the oocyte and preimplantation embryo, prevents precocious activation of Hox genes post-implantation. Without maternal SMCHD1, highly penetrant posterior homeotic transformations occur in the embryo. Hox genes are decorated with Polycomb marks H2AK119ub and H3K27me3 from the oocyte throughout early embryonic development; however, loss of maternal SMCHD1 does not deplete these marks. Therefore, we propose maternal SMCHD1 acts downstream of Polycomb marks to establish a chromatin state necessary for persistent epigenetic silencing and appropriate Hox gene expression later in the developing embryo. This is a striking role for maternal SMCHD1 in long-lived epigenetic effects impacting offspring phenotype. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink