Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's disease
| Autor: | Tian-Fang Jiang, Sheng-Di Chen, Qian Sun |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Parkinson's disease General Neuroscience Tau protein SOD2 Parkinson Disease Biology Mitochondrion medicine.disease medicine.disease_cause LRRK2 Neuroprotection Antioxidants PRDX3 03 medical and health sciences Oxidative Stress 030104 developmental biology 0302 clinical medicine Alzheimer Disease medicine biology.protein Humans Neuroscience 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Progress in neurobiology. 147 |
| ISSN: | 1873-5118 |
| Popis: | Oxidative stress reflects an imbalance between the overproduction and incorporation of free radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free radicals produced by oxidative stress are one of the common features in several experimental models of diseases. Free radicals affect both the structure and function of neural cells, and contribute to a wide range of neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Although the precise mechanisms that result in the degeneration of neurons and the relevant pathological changes remain unclear, the crucial role of oxidative stress in the pathogenesis of neurodegenerative diseases is associated with several proteins (such as α-synuclein, DJ-1, Amyloid β and tau protein) and some signaling pathways (such as extracellular regulated protein kinases, phosphoinositide 3-kinase/Protein Kinase B pathway and extracellular signal-regulated kinases 1/2) that are tightly associated with the neural damage. In this review, we present evidence, gathered over the last decade, concerning a variety of pathogenic proteins, their important signaling pathways and pathogenic mechanisms associated with oxidative stress in Parkinson's disease and Alzheimer's disease. Proper control and regulation of these proteins' functions and the related signaling pathways may be a promising therapeutic approach to the patients. We also emphasizes antioxidative options, including some new neuroprotective agents that eliminate excess reactive oxygen species efficiently and have a certain therapeutic effect; however, controversy surrounds some of them in terms of the dose and length of therapy. These agents require further investigation by clinical application in patients suffering Parkinson's disease and Alzheimer's disease. |
| Databáze: | OpenAIRE |
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