Surgical Treatment for Early Esophageal Squamous Cell Carcinoma
| Autor: | Geng Wang, Hao Zhang, Wei-Ping Yang, Yu-Ping Chen, Shaobin Chen, Hong-rui Weng, Jie-Sheng Yang, Di-tian Liu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Esophageal Neoplasms Epidemiology medicine.medical_treatment Carcinoma medicine Humans Survival rate Lymph node Aged Neoplasm Staging Retrospective Studies business.industry Carcinoma in situ Public Health Environmental and Occupational Health Mediastinum Middle Aged Prognosis medicine.disease Surgery Esophagectomy Survival Rate medicine.anatomical_structure Thoracotomy Oncology Lymphatic Metastasis Mediastinal lymph node Carcinoma Squamous Cell Lymph Node Excision Female Lymphadenectomy Radiology Lymph business Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 14:3825-3830 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2013.14.6.3825 |
| Popis: | More studies are needed to clarify treatments and prognosis of early esophageal squamous cell carcinoma (ESCC). This retrospective study was designed to review the outcome of surgical treatment for early ESCC, evaluate the results of a left thoracotomy for selected patients with early ESCC, and identify factors affecting lymph node metastases and survival. The clinicopathological data of 228 patients with early ESCC who underwent transthoracic esophagectomy with lymphadenectomy without preoperative adjuvant treatment were reviewed. The χ(2) test or Fisher's exact test were used to detect factors related to lymph node metastasis. Univariate and multivariate analyses were performed to identify prognostic factors. There were 152 males and 76 females with a median age of 55 years. Two hundred and eight patients underwent a left thoracotomy, and the remaining 20 patients with lymph nodes in the upper mediastinum more than 5 mm in short-axis diameter by computed tomography scan underwent a right thoracotomy. No lymph node metastasis was found in the 18 patients with carcinoma in situ, while lymph node metastases were detected in 1.6% (1/62) of patients with mucosal tumours and 18.2% (27/148) of patients with submucosal tumours. Only 7 patients showed upper mediastinal lymph node metastases in the follow-up. The 5- and 10-year overall survival rates were 81.4% and 70.1%, respectively. Only histologic grade (P0.001) and pT category (P=0.001) significantly correlated with the presence of lymph node metastases. In multivariate analysis, only histologic grade (P=0.026) and pT category (P=0.008) were independent prognostic factors. A left thoracotomy is acceptable for selected patients with early ESCC. Histologic grade and pT category affected the presence of lymph node metastases and were independent prognostic factors for early ESCC. |
| Databáze: | OpenAIRE |
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