Tuning the allosteric sequestration of anticancer drugs for developing cooperative nano-antidotes
| Autor: | Jovica D. Badjić, Curtis E. Moore, Tyler J. Finnegan, Kejia Shi, Xingrong Zhu, Zhiquan Lei, Weikun Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular Molecular Structure Hydrogen bond Chemistry Stereochemistry Allosteric regulation Antidotes Metals and Alloys Nanoparticle Cooperativity Antineoplastic Agents Hydrogen Bonding General Chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Nanostructures Hydrophobic effect Allosteric Regulation Nano Materials Chemistry Ceramics and Composites Molecule Anthracyclines Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Chemical communications (Cambridge, England). 56(8) |
| ISSN: | 1364-548X |
| Popis: | A dual-cavity basket 16-, holding six γ-aminobutyric acids at its termini, encapsulates variously sized aromatics 2-7+, including four anthracyclines (8+-11+), driven by the hydrophobic effect and hydrogen bonding (HB). In particular, the formation of stable (K = 1012 M-2) anthracycline complexes [(8+-11+)2⊂16-], assembled into nanoparticles, occurred with positive homotropic cooperativity (α = 4K2/K1 = 1.1 ± 0.3 × 102-1.3 ± 0.7 × 103) in PBS medium. Importantly, weakening the first binding event (K1, i.e. by removing HBs) turned the second one (K2) more favorable. The finding is of interest for developing cooperative nano-antidotes acting as biodetoxifying agents. |
| Databáze: | OpenAIRE |
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