Differences in MDS-UPDRS Scores Based on Hoehn and Yahr Stage and Disease Duration
| Autor: | Barbara C. Tilley, Eva Reiter, Klaus Seppi, Thomas Foltynie, Carlos Singer, Iciar Aviles-Olmos, Carmen Rodriguez-Blazquez, Michal Minár, Milan Grofik, Pille Taba, Vladimir Han, Henry Moore, Peter Valkovič, Alberto Bergareche-Yarza, Christopher G. Goetz, Eve Benchetrit, Matej Skorvanek, Graziella Mangone, Pablo Martinez-Martin, Anabel Chade, Anette Schrag, Werner Poewe, Norbert Kovács, Veronika Datieva, Amin Cervantes-Arriaga, Zuzana Gdovinova, Mario Alvarez-Sanchez, Nelida Garretto, Bernadette Pinter, Florence Cormier, Mari Muldmaa, Amelia Mendoza-Rodriguez, Juan Carlos Martínez-Castrillo, Oleg Levin, Jean-Christophe Corvol, Charline Benoit, Liis Kadastik-Eerme, David A. Gallagher, Tomoko Arakaki, Glenn T. Stebbins, Mayela Rodríguez-Violante, Monica M. Kurtis, Jing Huang, Karin Rallmann, Oscar S. Gershanik, Zsuzsanna Aschermann, Christoph Mueller |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gerontology medicine.medical_specialty Parkinson's disease Mds updrs Disease duration Hoehn and Yahr Part iii scale 03 medical and health sciences 0302 clinical medicine Rating scale Internal medicine medicine Stage (cooking) Motor assessment Research Articles Mean age Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) medicine.disease nervous system diseases 030104 developmental biology Neurology Neurology (clinical) disease duration Psychology 030217 neurology & neurosurgery |
| Zdroj: | Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| Popis: | BACKGROUND: The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) is a newly developed tool to assess Parkinson's disease (PD). Changes in scores on the scale over the course of PD, including increasing disease duration and Hoehn and Yahr (HY) stages, have not been described. The objectives of this study were to analyze MDS‐UPDRS scores on Parts I through IV and their differences based on HY stage and disease duration in a large cohort of patients with PD. METHODS: For this cross‐sectional study, demographic data and MDS‐UPDRS scores were collected, including HY stage. Subscores on MDS‐UPDRS Parts I through IV were analyzed using 1‐way analyses of variance for each HY stage and in 5‐year increments of disease duration. Part III (motor assessment) scores were analyzed separately for on and off states. RESULTS: The mean age of the 3206 patients was 65.8 ± 10.6 years, 53.3% were men, the mean disease duration was 11.5 ± 4.6 years, and the median HY stage was 2 (range, 0–5); 2156 patients were examined in an on state and 987 were examined in an off state. Scores for all MDS‐UPDRS parts increased significantly through HY stages 1 through 5, with an average increase of 3.8, 7.7, 14.6, and 2.0 points consecutively for parts I through IV, respectively. For the 5‐year increments of disease duration, MDS‐UPDRS subscores increased by an average of 1.6, 3.3, 4.2, and 1.4 points consecutively for parts I through IV, respectively. This increase was significant only during the first 15 years of disease for all 4 parts, including part III scores evaluated in both on and off states. CONCLUSIONS: MDS‐UPDRS scores for all 4 parts increase significantly with every HY stage and also with 5‐year increments of disease duration in the first 15 years of the disease. |
| Databáze: | OpenAIRE |
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