Adiponectin protects the rats liver against chronic intermittent hypoxia induced injury through AMP-activated protein kinase pathway
| Autor: | Xilong Zhang, Qiang Zhang, Ning Ding, Hanpeng Huang, Wen-Xiao Ding, Xianji Zhu, Yanbin Dong, Sean Z. Hutchinson, Xingya Gao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification medicine.medical_specialty Multidisciplinary Triglyceride biology Adiponectin AMPK Article 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Enzyme Endocrinology chemistry AMP-activated protein kinase Apoptosis Internal medicine biology.protein medicine Hepatic stellate cell Protein kinase A |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep34151 |
| Popis: | This study was performed to assess the effect of chronic intermittent hypoxia (CIH) on the liver, the associated mechanisms and the potential therapeutic roles of adiponectin (Ad). Sixty rats were randomly assigned to four groups: the normal control (NC), NC and Ad supplement (NC + Ad), CIH and CIH and Ad supplement (CIH + Ad) groups. The rats in the CIH and CIH + Ad groups were exposed to a hypoxic environment for 4 months. Rats in the NC + Ad and CIH + Ad groups were also treated with an intravenous injection of Ad (10 ug), twice a week. The plasma levels of hepatic enzymes, serum triglyceride, liver triglyceride, fasting blood glucose and hepatic cell apoptosis in hepatic tissue, were higher in the CIH group than in the NC and NC + Ad groups. However, the Ad supplementation in the CIH + Ad group rescued the hepatic tissue insult by activating the AMP-activated protein kinase (AMPK) pathway. In conclusion, Ad could protect against CIH-induced hepatic injury partly through the AMPK pathway. |
| Databáze: | OpenAIRE |
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