Increased prothrombin fragment 1 + 2 and D-dimer in first-degree relatives of type 2 diabetic patients. Prethrombotic state in relatives of type 2 diabetic patients
| Autor: | P. Domenech, José Manuel Fernández-Real, M. Fernández-Castañer, F. Martínez-Brotons, I. Camps |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Type 2 diabetes Fibrinogen Statistics Nonparametric Fibrin Fibrinogen Degradation Products Endocrinology Risk Factors Internal medicine Diabetes mellitus D-dimer Internal Medicine Medicine Humans Family First-degree relatives Protein Precursors business.industry PROTHROMBIN FRAGMENT 1.2 Insulin Age Factors Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease Blood Coagulation Factors Peptide Fragments Diabetes Mellitus Type 2 Hyperglycemia Female Prothrombin business medicine.drug |
| Zdroj: | Acta diabetologica. 33(2) |
| ISSN: | 0940-5429 |
| Popis: | To evaluate whether or not activated coagulation is present in the preclinical phases of type 2 diabetes mellitus, we studied 46 non-diabetic first-degree relatives of type 2 diabetic patients and 21 matched controls with no family history of diabetes. We determined the plasma levels of prothrombin fragment 1 + 2, D-dimer, fibrinogen, plasminogen activator inhibitor type 1, tissue plasminogen activator, von Willebrand factor and coagulation factors VII and VIII. Glucose tolerance, beta-cell function and insulin sensitivity were assessed in all subjects by a continuous glucose infusion of 5 mg.kg ideal body weight-1.min-1 for 60 min with model assessment of glucose, insulin and C-peptide values. Plasma levels of prothrombin fragment 1 + 2 (median 1.24 vs 0.68 nmol.l-1; P = 0.0001) and D-dimer (331 vs 254 micrograms.l-1 UEF; P = 0.018) were higher in relatives, without significant differences in the other haemostatic variables. Relatives showed higher fasting (5.5 vs 4.9 mmol.l-1, P = 0.004) and post-infusion (9.3 vs 8.3 mmol.l-1, P = 0.02) serum glucose, no differences in insulin or C-peptide levels, lower beta-cell function (122% vs 147%; P = 0.02) and no significant differences in insulin sensitivity. Fifteen relatives were glucose-intolerant and had lower beta-cell function and insulin sensitivity than glucose-tolerant relatives. Both subsets of relatives exhibited higher levels of prothrombin fragment 1 + 2 and D-dimer than control subjects. Thus, first-degree relatives of type 2 diabetic patients present an activated coagulation, even in the absence of minor degrees of glucose intolerance. These abnormalities can play a role in the pathogenesis of cardiovascular diseases frequently seen at diagnosis of type 2 diabetes. |
| Databáze: | OpenAIRE |
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