GABAA Receptors at Hippocampal Mossy Fibers
| Autor: | Ruth Fabian-Fine, Arnaud Ruiz, Matthew C. Walker, Dimitri M. Kullmann, Ricardo Scott, Dmitri A. Rusakov |
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| Jazyk: | angličtina |
| Předmět: |
Agonist
Male medicine.drug_class Neuroscience(all) Guinea Pigs Neurotransmission Hippocampal formation In Vitro Techniques Hippocampus Synaptic Transmission gamma-Aminobutyric acid Article GABAA-rho receptor Membrane Potentials Rats Sprague-Dawley medicine Animals GABA-A Receptor Agonists Receptor gamma-Aminobutyric Acid GABAA receptor Chemistry General Neuroscience musculoskeletal neural and ocular physiology Long-term potentiation Receptors GABA-A Rats nervous system Mossy Fibers Hippocampal Neuroscience medicine.drug |
| Zdroj: | Neuron. (6):961-973 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/S0896-6273(03)00559-2 |
| Popis: | Presynaptic GABAA receptors modulate synaptic transmission in several areas of the CNS but are not known to have this action in the cerebral cortex. We report that GABAA receptor activation reduces hippocampal mossy fibers excitability but has the opposite effect when intracellular Cl− is experimentally elevated. Synaptically released GABA mimics the effect of exogenous agonists. GABAA receptors modulating axonal excitability are tonically active in the absence of evoked GABA release or exogenous agonist application. Presynaptic action potential-dependent Ca2+ transients in individual mossy fiber varicosities exhibit a biphasic dependence on membrane potential and are altered by GABAA receptors. Antibodies against the α2 subunit of GABAA receptors stain mossy fibers. Axonal GABAA receptors thus play a potentially important role in tonic and activity-dependent heterosynaptic modulation of information flow to the hippocampus. |
| Databáze: | OpenAIRE |
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