Uraemic Encephalopathy in a Persian Cat with Chronic Kidney Disease
| Autor: | Tais Meziara Wilson, Davi Emanuel Ribeiro de Sousa, Mizael Machado, Alexandra A. B. Gonçalves, Christine Souza Martins, Márcio Botelho de Castro |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Glossitis 040301 veterinary sciences Interstitial nephritis Grey matter Kidney 030308 mycology & parasitology Pathology and Forensic Medicine 0403 veterinary science White matter 03 medical and health sciences Lethargy Fatal Outcome medicine Animals Renal Insufficiency Chronic 0303 health sciences Brain Diseases General Veterinary business.industry Acute kidney injury 04 agricultural and veterinary sciences medicine.disease medicine.anatomical_structure Cerebral cortex Astrocytes business Kidney disease |
| Zdroj: | Journal of comparative pathology. 180 |
| ISSN: | 1532-3129 |
| Popis: | Uraemic encephalopathy (UE) is rarely associated with acute kidney injury or chronic kidney disease in domestic animals, and we now report the first case in a cat. The animal presented with hypothermia, apathy, lethargy, depression, severe dehydration, uraemic breath, elevated serum urea nitrogen and creatine concentrations, and eventual seizures and coma prior to death. Gross necropsy findings included severe bilateral renal scarring, ulcerative stomatitis and glossitis, and uraemic gastropathy. Microscopic lesions of diffuse interstitial fibrosis, multifocal mineralization and lymphoplasmacytic interstitial nephritis were seen in the kidneys. There was symmetrical, bilateral spongy vacuolation of the white matter of the basal nuclei and cerebellum and Alzheimer type II astrocytes in the cerebral cortex and hippocampus. Glial fibrillary acid protein immunolabelling was absent or faint in astrocytes of the cerebral grey matter. UE should be included in the differential diagnosis in animals with chronic kidney disease and neurological signs. |
| Databáze: | OpenAIRE |
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