Effects of the N/L-type calcium channel blocker cilnidipine on nephropathy and uric acid metabolism in hypertensive patients with chronic kidney disease (J-CIRCLE study)
| Autor: | Masayoshi Soma, Takafumi Ito, Masami Fujita, Yasumi Ohno, Tomoyuki Hikita, Hironao Itakura, Masato Takahashi, Kazuhiko Nakai, Shunya Uchida, Kageki Ito, Yuko Takahashi, Koichi Mochizuki, Takashi Morita, Tomoaki Saito, Masahiro Sugawara, Isu Shin, Shigeki Mizuno |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Dihydropyridines Hypertension Renal medicine.drug_class Endocrinology Diabetes and Metabolism Blood Pressure Calcium channel blocker urologic and male genital diseases Nephropathy chemistry.chemical_compound Japan Internal medicine Internal Medicine medicine Albuminuria Humans Diabetic Nephropathies Amlodipine Aged Aged 80 and over Creatinine Original Paper Cross-Over Studies Nephrosclerosis Dose-Response Relationship Drug business.industry Drug Substitution Cilnidipine Middle Aged medicine.disease Calcium Channel Blockers Original Papers Uric Acid Endocrinology chemistry Uric acid Kidney Failure Chronic Female medicine.symptom Cardiology and Cardiovascular Medicine business Kidney disease medicine.drug |
| Zdroj: | The Journal of Clinical Hypertension |
| ISSN: | 1751-7176 |
| Popis: | This study assessed the urinary albumin/creatinine ratio (ACR) and uric acid metabolism in 70 hypertensive patients with chronic kidney disease in whom urinary ACR had remained ≥30 mg/g under the treatment of the L-type calcium channel blocker amlodipine. Three months after switching to the N/L-type calcium channel blocker cilnidipine, blood pressure (BP) did not change; however, urinary ACR significantly decreased with cilnidipine. Serum uric acid levels showed no significant change. In cases where uric acid production had been high (urinary uric acid/creatinine ratio ≥0.5), the urinary uric acid/creatinine ratio decreased significantly after cilnidipine treatment, suggesting that cilnidipine can suppress excessive uric acid formation. These results suggest that switching from amlodipine to cilnidipine results in a significant reduction in urinary ACR as well as significant reduction in uric acid production. Thus, cilnidipine is more useful than amlodipine in improving albuminuria and uric acid metabolism in hypertensive patients with chronic kidney disease. |
| Databáze: | OpenAIRE |
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