Synthetic Pot: Not Your Grandfather’s Marijuana
| Autor: | Benjamin M. Ford, William E. Fantegrossi, Paul L. Prather, Sherrica Tai |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology Drug Cannabinoids Illicit Drugs Substance-Related Disorders business.industry media_common.quotation_subject Toxicology Article 03 medical and health sciences 030104 developmental biology 0302 clinical medicine mental disorders Synthetic cannabinoids medicine Animals Humans Tetrahydrocannabinol business 030217 neurology & neurosurgery medicine.drug media_common |
| Zdroj: | Trends in Pharmacological Sciences. 38:257-276 |
| ISSN: | 0165-6147 |
| DOI: | 10.1016/j.tips.2016.12.003 |
| Popis: | In the early 2000s in Europe and shortly thereafter in the USA, it was reported that ‘legal' forms of marijuana were being sold under the name K2 and/or Spice. Active ingredients in K2/Spice products were determined to be synthetic cannabinoids (SCBs), producing psychotropic actions via CB 1 cannabinoid receptors, similar to those of Δ 9 -tetrahydrocannabinol (Δ 9 -THC), the primary active constituent in marijuana. Often abused by adolescents and military personnel to elude detection in drug tests due to their lack of structural similarity to Δ 9 -THC, SCBs are falsely marketed as safe marijuana substitutes. Instead, SCBs are a highly structural diverse group of compounds, easily synthesized, which produce very dangerous adverse effects occurring by, as of yet, unknown mechanisms. Therefore, available evidence indicates that K2/Spice products are clearly not safe marijuana alternatives. |
| Databáze: | OpenAIRE |
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