Multimodal analgesia versus traditional opiate based analgesia after cardiac surgery, a randomized controlled trial
| Autor: | Lars Willy Andersen, Peter Skov Olsen, Nikolaj Bang Lilleoer, Michael Jaeger Wanscher, Sulman Rafiq, Albert Navne, Daniel A Steinbrüchel |
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| Rok vydání: | 2014 |
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Pulmonary and Respiratory Medicine medicine.medical_specialty Cyclohexanecarboxylic Acids Nausea medicine.medical_treatment Ibuprofen Dexamethasone law.invention Postoperative pain Randomized controlled trial law medicine Humans Pain Management Prospective Studies Myocardial infarction Amines Cardiac Surgical Procedures Stroke gamma-Aminobutyric Acid Acetaminophen Aged Analgesics Pain Postoperative Morphine business.industry General Medicine Cardiac surgery Middle Aged medicine.disease NSAID Surgery Analgesics Opioid Regimen Cardiothoracic surgery Median sternotomy Anesthesia Multimodal Vomiting Drug Therapy Combination Female Gabapentin Analgesia medicine.symptom Cardiology and Cardiovascular Medicine business Research Article |
| Zdroj: | Journal of Cardiothoracic Surgery |
| ISSN: | 1749-8090 |
| DOI: | 10.1186/1749-8090-9-52 |
| Popis: | Background To evaluate if an opiate sparing multimodal regimen of dexamethasone, gabapentin, ibuprofen and paracetamol had better analgesic effect, less side effects and was safe compared to a traditional morphine and paracetamol regimen after cardiac surgery. Methods Open-label, prospective randomized controlled trial. 180 patients undergoing cardiac procedures through median sternotomy, were included in the period march 2007- August 2009. 151 patients were available for analysis. Pain was assessed with the 11-numeric rating scale (11-NRS). Results Patients in the multimodal group demonstrated significantly lower average pain scores from the day of surgery throughout the third postoperative day. Extensive nausea and vomiting, was found in no patient in the multimodal group but in 13 patients in the morphine group, p |
| Databáze: | OpenAIRE |
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