Critical sites: a semantic approach to protein sequences. Application to the HIV-1 envelope molecule
| Autor: | W Issing, Jean-François Zagury, E Thoreau, F Pellion, JP Mbika, L Fall, Daniel Zagury, Bizzini Bernard, Hubert Cantalloube, Claude Carelli, Jacky Bernard, JP Momon, Isabelle Callebaut, MH Cosme, A Lachgar, Arsène Burny, Ammar Achour |
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| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Binding Sites Molecular Sequence Data Human immunodeficiency virus (HIV) General Medicine Computational biology In Vitro Techniques Biology medicine.disease_cause Hiv 1 envelope Virology Investigation methods Viral Envelope Proteins CD4 Antigens HIV-1 medicine Selection (linguistics) Data bank Amino Acid Sequence Software |
| Zdroj: | Biomedicine & Pharmacotherapy. 46:343-351 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/0753-3322(92)90302-n |
| Popis: | We have designed two software systems allowing the study of proteins through a comparison to those stored in data banks. The first one, “Automat”, locates in a systematic manner all identities shared by a given protein and the proteins in a data bank. The second, “Critic” enables the selection of specific segments in a given molecule by comparing them with those gathered in a data bank. These sites were termed “critical” since they mostly correspond to functional sites (active sites) of the well-known proteins which were studied with the aid of this program (somatostatin, insulin. IL2, etc). Automat allowed us to reveal homologies between HIV-1 and the CD4, which have remained unsolved until now. These similitudes proved to be critical sites (according to Critic). The putative involvement of these sites in the physiopathological processes as induced by HIV-1 are worth considering since the results of our experiments are consistent with this assumption. HIV / automat / critic / protein |
| Databáze: | OpenAIRE |
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