Immune Responses Following Mouse Peripheral Nerve Xenotransplantation in Rats
| Autor: | Jia-Bing Sun, Laijin Lu, Xiguang Sun, Zhi-Gang Liu, Xu Gong, Jian-Li Cui |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Graft Rejection
Interleukin 2 Pathology medicine.medical_specialty Necrosis Article Subject lcsh:Biotechnology Health Toxicology and Mutagenesis Xenotransplantation medicine.medical_treatment Transplantation Heterologous lcsh:Medicine Biology Rats Sprague-Dawley Interferon-gamma Mice Immune system lcsh:TP248.13-248.65 Genetics medicine Animals Interferon gamma Peripheral Nerves Molecular Biology Mice Inbred BALB C Tumor Necrosis Factor-alpha lcsh:R General Medicine Th1 Cells Rats Transplantation Mononuclear cell infiltration Immunology Interleukin-2 Molecular Medicine Female Tumor necrosis factor alpha medicine.symptom Research Article Biotechnology medicine.drug |
| Zdroj: | Journal of Biomedicine and Biotechnology Journal of Biomedicine and Biotechnology, Vol 2009 (2009) |
| ISSN: | 1110-7251 1110-7243 |
| DOI: | 10.1155/2009/412598 |
| Popis: | Xenotransplantation offers a potentially unlimited source for tissues and organs for transplantation, but the strong xenoimmune responses pose a major obstacle to its application in the clinic. In this study, we investigate the rejection of mouse peripheral nerve xenografts in rats. Severe intragraft mononuclear cell infiltration, graft distension, and necrosis were detected in the recipients as early as 2 weeks after mouse nerve xenotransplantation. The number of axons in xenografts reduced progressively and became almost undetectable at week 8. However, mouse nerve xenotransplantation only led to a transient and moderate increase in the production of Th1 cytokines, including IL-2, IFN-γ, and TNF-α. The data implicate that cellular immune responses play a critical role in nerve xenograft rejection but that further identification of the major effector cells mediating the rejection is required for developing effective means to prevent peripheral nerve xenograft rejection. |
| Databáze: | OpenAIRE |
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