Expression of components of the RAS during prolonged blockade at different levels in primates
| Autor: | Martin P. Kelly, Nilesh J. Samani, J. M. Wood, F. Cumin |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors Physiology medicine.drug_class Endocrinology Diabetes and Metabolism Angiotensinogen Tetrazoles Angiotensin-Converting Enzyme Inhibitors Blood Pressure Biology Kidney Renin inhibitor Renin-Angiotensin System Angiotensin Receptor Antagonists Physiology (medical) Internal medicine Renin Renin–angiotensin system medicine Animals RNA Messenger Angiotensin II Antibodies Monoclonal Callithrix Valine Benazeprilat Benzazepines Endocrinology medicine.anatomical_structure Liver Valsartan Enzyme inhibitor ACE inhibitor biology.protein Female Oligopeptides medicine.drug |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 267:E612-E619 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1994.267.4.e612 |
| Popis: | To assess the effects of inhibition of the renin-angiotensin system at different levels on plasma concentrations of components of the system and on renin and angiotensinogen gene expression, marmosets on a low-sodium diet were treated for 1 wk by continuous intraperitoneal infusion with either the renin inhibitor CGP-29287, the ACE inhibitor benazeprilat, the angiotensin II antagonist valsartan, the renin inhibitory monoclonal antibody R-3-36-16, or vehicle. Plasma total immunoreactive renin increased (14- to 20-fold) after all three modes of interference. Plasma angiotensinogen was significantly reduced in the benazeprilat- and valsartan-treated marmosets but not in the CGP-29287-treated animals. Plasma concentration of angiotensin II was significantly decreased in the benazeprilat-, CGP-29287-, and R-3-36-16-treated marmosets and was increased in the valsartan-treated marmosets. Kidney renin mRNA level increased 8- to 15-fold in all groups. Hepatic angiotensinogen mRNA level increased with CGP-29287 treatment but decreased with the other treatments. Kidney angiotensinogen mRNA level was not affected by any treatment. Different modes of inhibition of the renin-angiotensin system have different effects on plasma components of the system and liver angiotensinogen expression. |
| Databáze: | OpenAIRE |
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