Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study

Autor: Laura F. DeFina, Carolyn E. Barlow, William L. Haskell, Nathan L. Tintle, William S. Harris, Stephen W. Farrell, Andjelka Pavlovic, Kenneth H. Cooper, David Leonard
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Oncology
Male
eicosapentaenoic acid
Erythrocytes
Prostate cancer
0302 clinical medicine
Longitudinal Studies
Prospective Studies
Prospective cohort study
chemistry.chemical_classification
Aged
80 and over
Nutrition and Dietetics
omega-3 fatty acids
Hazard ratio
Fishes
docosahexaenoic acid
Middle Aged
Fish oil
prostate cancer
Eicosapentaenoic acid
Docosahexaenoic acid
030220 oncology & carcinogenesis
Biomarker (medicine)
biomarker
lipids (amino acids
peptides
and proteins)
epidemiology
lcsh:Nutrition. Foods and food supply
Polyunsaturated fatty acid
Adult
medicine.medical_specialty
Docosahexaenoic Acids
prospective cohort
lcsh:TX341-641
Article
03 medical and health sciences
Fish Oils
Internal medicine
Fatty Acids
Omega-3
medicine
Animals
Humans
Aged
business.industry
Prostatic Neoplasms
medicine.disease
030104 developmental biology
chemistry
Dietary Supplements
business
Biomarkers
Food Science
Zdroj: Nutrients
Nutrients, Vol 13, Iss 384, p 384 (2021)
Volume 13
Issue 2
ISSN: 2072-6643
Popis: Background: The association between long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) and prostate cancer (PC) remains unclear. Methods: We compared incident PC rates as a function of the Omega-3 Index [O3I, erythrocyte eicosapentaenoic and docosahexaenoic acids (EPA + DHA)] in 5607 men (40&ndash
80 years of age) seen at the Cooper Clinic who were free of PC at baseline. The average follow-up was 5.1 ±
2.8 years until censoring or reporting a new PC diagnosis. Proportional hazards regression was used to model the linear association between baseline O3I and the age-adjusted time to diagnosis. A meta-analysis of n-3 PUFA biomarker-based studies and incident PC was updated with the present findings. Results: A total of 116 cases of incident PC were identified. When O3I was examined as a continuous variable, the age-adjusted hazard ratio (HR) (95% CI) was 0.98 (0.89, 1.07
p = 0.25) for each 1% increment in the O3I. The updated meta-analysis with 10 biomarker-based studies found no significant relationship between EPA or DHA levels and risk for PC. Conclusions: We find no evidence in this study nor in a meta-analysis of similar studies that consuming n-3 PUFA-rich fish or using fish oil supplements affects the risk of PC.
Databáze: OpenAIRE
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