New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 3
| Autor: | Yasuyuki, Takeda, Toshiharu, Yoshino, Kouichi, Uoto, Jun, Chiba, Takashi, Ishiyama, Michio, Iwahana, Takeshi, Jimbo, Noriko, Tanaka, Hirofumi, Terasawa, Tsunehiko, Soga |
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| Rok vydání: | 2003 |
| Předmět: |
Paclitaxel
Cell Survival Organic Chemistry Clinical Biochemistry Melanoma Experimental Molecular Conformation Pharmaceutical Science Crystallography X-Ray Antineoplastic Agents Phytogenic Biochemistry Mice Solubility Drug Discovery Tumor Cells Cultured Animals Humans Molecular Medicine Indicators and Reagents Drug Screening Assays Antitumor Molecular Biology Neoplasm Transplantation |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 13:185-190 |
| ISSN: | 0960-894X |
| Popis: | We synthesized novel water-soluble and orally active taxane analogues, 7-deoxy-9beta-dihydro-9,10-O-acetal taxanes. Cytotoxicities of the synthetic compounds were greater than those of paclitaxel and docetaxel, especially against resistant cancer cell lines expressing P-glycoprotein. In addition, some compounds showed potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration. |
| Databáze: | OpenAIRE |
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