Effects of Dehydroepiandrosterone Sulfate on Blood Pressure and Aldosterone Level via μ-Opioid Receptors
| Autor: | Vladimir A. Kozlov, E. T. Obut, T. A. Erdinieva, S. A. Egorova, T. A. Obut, T. Yu. Dement’eva, M. V. Ovsukova |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Stress exposure Receptors Opioid mu Blood Pressure General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Dehydroepiandrosterone sulfate Internal medicine medicine Animals Rats Wistar Receptor Aldosterone Antihypertensive Agents Dehydroepiandrosterone Sulfate General Medicine Rats body regions Endocrinology Blood pressure chemistry Opioid Aldosterone blood Stress Psychological medicine.drug Hormone |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 156:35-37 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Dehydroepiandrosterone sulfate (30 mg/kg) produced a hypotensive effect by preventing stress-induced surge of hypertensive hormone aldosterone in rats after manifold repeated, but not single stress exposure. Both effects were realized via μ-opioid receptors. Thus, μ-opioid mechanism of blockage of aldosterone surge can underlay the hypotensive effects of dehydroepiandrosterone sulfate at least under conditions of manifold repeated exposures. |
| Databáze: | OpenAIRE |
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