Endocycles support tissue growth and regeneration of the adult Drosophila accessory gland
| Autor: | Allison M. Box, Samuel Jaimian Church, Shyama Nandakumar, Dilan Prasad, Ariana Afrakhteh, Russell S. Taichman, Laura Buttitta |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
biology Regeneration (biology) 030302 biochemistry & molecular biology Cell cycle biology.organism_classification Epithelium Cell biology 03 medical and health sciences medicine.anatomical_structure Downregulation and upregulation Prostate medicine Ploidy Mating Drosophila melanogaster 030304 developmental biology |
| DOI: | 10.1101/719013 |
| Popis: | The Drosophila melanogaster male accessory gland is a functional analog of the mammalian prostate containing two secretory epithelial cell types, termed main and secondary cells. This tissue is responsible for making and secreting seminal fluid proteins and other molecules that contribute to successful reproduction. Here we show that similar to the mammalian prostate, this tissue grows with age and can undergo functional regeneration post-damage. We describe a post-eclosion endocycle required for gland maturation, that is dependent on juvenile hormone signaling. In addition, the differentiated binucleated main cells of the adult accessory gland continue to undergo rare endocycles throughout physiological aging to increase DNA content and cell size. Accessory gland cells remain poised to endocycle and upregulation of signals that promote endocycling and tissue growth are sufficient to trigger dramatic increases in cell ploidy. We provide evidence that the main cells of this tissue remain poised to enter the endocycle to assist in tissue regrowth after damage, providing a novel model for postmitotic regeneration in a binucleate tissue. |
| Databáze: | OpenAIRE |
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