Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats
| Autor: | Camila Gimenes, A. H. R. Takamoto, N. P. Xavier, C. M. Rosa, Dijon Henrique Salomé de Campos, Katashi Okoshi, M. D. M. Cezar, Marina Politi Okoshi, Antonio Carlos Cicogna, Ana Angélica Henrique Fernandes, G. N. Guirado, Rodrigo Gimenes |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade do Sagrado Coração (USC) |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Article Subject Endocrinology Diabetes and Metabolism Diastole Physical exercise medicine.disease_cause lcsh:Diseases of the endocrine glands. Clinical endocrinology Diabetes Mellitus Experimental Endocrinology Physical Conditioning Animal Internal medicine Diabetes mellitus medicine Animals Aerobic exercise Rats Wistar Ventricular remodeling Papillary muscle lcsh:RC648-665 Ventricular Remodeling business.industry Myocardium Heart Streptozotocin medicine.disease Exercise Therapy Rats Oxidative Stress medicine.anatomical_structure business Oxidative stress Research Article medicine.drug |
| Zdroj: | Journal of Diabetes Research, Vol 2015 (2015) Journal of Diabetes Research PubMed Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 2314-6753 2314-6745 |
| Popis: | Made available in DSpace on 2015-12-07T15:31:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2015. Added 1 bitstream(s) on 2015-12-07T15:52:34Z : No. of bitstreams: 1 PMC4609864.pdf: 1437164 bytes, checksum: 4ac08666cb65268ebe8ec0a7a2e538ae (MD5) We evaluated the effects of a low intensity aerobic exercise protocol on cardiac remodeling and myocardial function in diabetic rats. Wistar rats were assigned into four groups: sedentary control (C-Sed), exercised control (C-Ex), sedentary diabetes (DM-Sed), and exercised diabetes (DM-Ex). Diabetes was induced by intraperitoneal injection of streptozotocin. Rats exercised for 9 weeks in treadmill at 11 m/min, 18 min/day. Myocardial function was evaluated in left ventricular (LV) papillary muscles and oxidative stress in LV tissue. Statistical analysis was given by ANOVA or Kruskal-Wallis. Echocardiogram showed diabetic groups with higher LV diastolic diameter-to-body weight ratio and lower posterior wall shortening velocity than controls. Left atrium diameter was lower in DM-Ex than DM-Sed (C-Sed: 5.73 ± 0.49; C-Ex: 5.67 ± 0.53; DM-Sed: 6.41 ± 0.54; DM-Ex: 5.81 ± 0.50 mm; P < 0.05 DM-Sed vs C-Sed and DM-Ex). Papillary muscle function was depressed in DM-Sed compared to C-Sed. Exercise attenuated this change in DM-Ex. Lipid hydroperoxide concentration was higher in DM-Sed than C-Sed and DM-Ex. Catalase and superoxide dismutase activities were lower in diabetics than controls and higher in DM-Ex than DM-Sed. Glutathione peroxidase activity was lower in DM-Sed than C-Sed and DM-Ex. Conclusion. Low intensity exercise attenuates left atrium dilation and myocardial oxidative stress and dysfunction in type 1 diabetic rats. Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil ; Sagrado Coração University, Bauru, SP, Brazil. Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil. Department of Chemistry and Biochemistry, Institute of Biosciences, São Paulo State University (UNESP), Brazil. Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil ; Sagrado Coração University, Bauru, SP, Brazil. Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), S/N, Rubião Junior District, 18618 970 Botucatu, SP, Brazil. Department of Chemistry and Biochemistry, Institute of Biosciences, São Paulo State University (UNESP), Brazil. |
| Databáze: | OpenAIRE |
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